贝投体育8059

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贝投体育8059: 鎴愰兘鐢熺墿鎵€鍗犲浗寮哄洟闃熻В鏋愪簡(R)-閫夋嫨鎬ц嫰涔欑儻鍗曞姞姘ч叾鐨勬櫠浣撶粨鏋勫苟鎻ず鍏剁珛浣撹皟鎺ф満鍒
鏉ユ簮锛鐢熸€佺幆澧冧慨澶嶄腑蹇 鏃堕棿锛2025-07-31

鍏夊绾幆姘у寲鍚堢墿鏄埗澶囪澶氬尰鑽€佸啘鑽€佸ぉ鐒舵椿鎬х墿璐ㄧ殑閲嶈鍓嶄綋锛岀儻鐑冧笉瀵圭О鐜哀鍖栨槸鍒跺鍏夊绾幆姘ф渶鐩存帴鏈夋晥鐨勬柟娉曚箣涓€銆傝嫰涔欑儻鍗曞姞姘ч叾鍙互鍌寲閮ㄥ垎鐑儍涓嶅绉扮幆姘у寲鍒跺鍏夊绾(R)-鎴(S)-鐜哀鍖栧悎鐗┿€傜劧鑰岋紝璇ラ叾鍌寲鐑儍涓嶅绉扮幆姘у寲鐨勭珛浣撹皟鎺ф満鍒跺皻涓嶆竻妤氾紝闃荤浜嗛€氳繃铔嬬櫧璐ㄥ伐绋嬫敼閫犺幏寰楃珛浣撻€夋嫨鎬ч珮涓斿簳鐗╄氨瀹芥硾鐨勯叾鍒跺墏銆

涓鸿В鍐充笂杩伴棶棰橈紝涓浗绉戝闄㈡垚閮界敓鐗╃爺绌舵墍鑱斿悎涓浗绉戝闄㈡繁鍦冲厛杩涢櫌浠ュ強娌冲崡鍐滀笟澶у锛岃В鏋愪簡(R)-閫夋嫨鎬ц嫰涔欑儻鍗曞姞姘ч叾SeStyA鏅朵綋缁撴瀯锛岀粨鍚堣绠楁ā鎷熷垎鏋愶紝闃愰噴浜(R)-閫夋嫨鎬ц嫰涔欑儻鍗曞姞姘ч叾鍌寲鐑儍鐜哀鍖栫殑绔嬩綋璋冩帶鏈哄埗锛屼负鏋勫缓鍌寲涓嶅悓搴曠墿鐨(R)-鎴(S)-绔嬩綋閫夋嫨鎬х幆姘у寲鐨勭獊鍙樹綋鎻愪緵鐞嗚鎸囧銆

鐮旂┒鍥㈤槦棣栧厛瑙f瀽浜嗘潵鑷摼闇夎弻Streptomyces vilmorinianum鐨(R)-閫夋嫨鎬ц嫰涔欑儻鍗曞姞姘ч叾SeStyA鏅朵綋缁撴瀯锛堝浘1锛夛紝缁撳悎鍒嗗瓙鍔ㄥ姏瀛︽ā鎷燂紝纭畾娲绘€т腑蹇冪殑A59銆丄312銆丼178鍜孉219浣嶇偣鍙兘涓烘帶鍒惰閰跺偓鍖栫幆姘у寲绔嬩綋閫夋嫨鎬х殑鍏抽敭浣嶇偣銆傞€氳繃鐐圭獊鍙樺強鍒嗘瀽锛屽彂鐜癈=C杩戠娈嬪熀锛圓59鍜孉312锛変笌杩滅娈嬪熀锛圫178鍜孉219锛夊ぇ灏忓喅瀹氳閰跺偓鍖栫殑绔嬩綋閫夋嫨鎬с€傛€讳綋鏉ヨ锛岀珛浣撻€夋嫨鎬ф満鍒堕伒寰€滄嫈娌斥€濇ā寮忥細澶ц繎绔畫鍩哄拰灏忚繙绔畫鍩哄皢璇ラ叾鈥滄媺鍚戔€(R)-绔嬩綋鍋忓ソ鎬э紝涓庝箣鐩稿弽锛屽皬杩戠娈嬪熀鍜屽ぇ杩滅娈嬪熀灏嗚閰垛€滄媺鍚戔€(S)-绔嬩綋鍋忓ソ鎬с€傝繘涓€姝ワ紝璇モ€滄嫈娌斥€濇ā寮忓湪鍏跺畠鑻箼鐑崟鍔犳哀閰AaStyA鍜NaStyA涓緱鍒伴獙璇侊紙鍥2锛夈€

鍥1.SeStyA鏅朵綋缁撴瀯鍙婂奖鍝嶅叾鍌寲绔嬩綋閫夋嫨鎬х殑鍏抽敭浣嶇偣瑙f瀽

鍥2. C=C鐨勮繎杩滅娈嬪熀瀵硅嫰涔欑儻鍗曞姞姘ч叾鍌寲鐜哀鍖栫珛浣撻€夋嫨鎬у奖鍝

鑻箼鐑崟鍔犳哀閰SeStyA (a鍜宐), AaStyA (c鍜宒), NaStyA (e鍜宖) 鍙婂叾绐佸彉浣撳偓鍖栧姘嫰涔欑儻 (a, c鍜宔) 鍜岃嫰涔欑儻 (b, d鍜宖)鐜哀鍖栥€


鍦ㄨ鈥滄嫈娌斥€濇ā寮忕珛浣撴帶鍒舵満鍒剁殑鎸囧涓嬶紝鐮旂┒鍥㈤槦娣卞叆鍦板垎鏋愪簡鍚勪綅鐐归棿鐨勫崗鍚屾晥搴旓紝骞舵垚鍔熸瀯寤轰簡涓€绯诲垪閽堝涓嶅悓绫诲瀷鍖栧悎鐗╁叿鏈変紭寮傜殑(R)-鎴(S)-绔嬩綋閫夋嫨鎬х殑绐佸彉浣擄紙鍥3锛夈€

鍥3. SeStyA锛堝乏锛夊強鍏剁獊鍙樹綋锛堝彸锛夌珛浣撻€夋嫨鎬у偓鍖栦笉鍚岀儻鐑冪幆姘у寲

涓庢鍚屾椂锛岄€氳繃鍒嗗瓙鍔ㄥ姏瀛︽ā鎷熼槓鏄庝簡璇モ€滄嫈娌斥€濇ā寮忕殑鍒嗗瓙鍩虹銆傜粨鏋滄樉绀猴細搴曠墿鍦ㄥ惈澶ц繙绔獊鍙樹綋S178Y涓互Re-face鏋勫瀷缁撳悎鐨勮嚜鐢辫兘浣庝簬Si-face鏋勫瀷锛岀敓鎴(S)-鐜哀浜х墿锛涜€屽簳鐗╁湪鍚ぇ杩戠灏忚繙绔獊鍙樹綋Mut4R锛圫178G/F57A/A312F/A59M锛変腑浠Si-face鏋勫瀷缁撳悎鐨勮嚜鐢辫兘浣庝簬Re-face鏋勫瀷锛岀敓鎴(R)-鐜哀浜х墿锛堝浘4锛夈€傚洜姝わ紝搴曠墿鍦ㄩ叾鍌寲娲绘€т腑鐨勭粨鍚堟瀯鍨嬪喅瀹氫簡璇ラ叾鍌寲鐨勭珛浣撻€夋嫨鎬с€

鍥4. SeStyA鍙婂叾绐佸彉浣撲笌涓嶅悓鏋勮薄搴曠墿鐨勭粨鍚堣嚜鐢辫兘鍒嗘瀽

鐩稿叧鐮旂┒浠モ€淪tructural and鈥侻echanistic Insight into the Enantioselectivity of (R)-Selective Styrene Monooxygenases: A Tug-of-War between Proximal and Distal Residues"涓洪锛屽彂琛ㄤ簬涓闄竴鍖篢OP鏈熷垔Angewandte Chemie International Edition涓婏紙IF 16.9锛1鍖簍op锛夈€傛垚閮界敓鐗╂墍鍗氬+鐮旂┒鐢熸潕鎵ф湸鍜屼腑鍥界瀛﹂櫌娣卞湷鍏堣繘闄㈢帇鍏拌吘涓鸿鏂囧叡鍚岀涓€浣滆€咃紝娌冲崡鍐滀笟澶у鏋楁櫀鍓暀鎺堛€佷腑鍥界瀛﹂櫌娣卞湷鍏堣繘闄㈠懆浣虫捣鐮旂┒鍛樺拰鎴愰兘鐢熺墿鎵€鍚翠腑鏌崇爺绌跺憳涓哄叡鍚岄€氳浣滆€呫€傝鐮旂┒寰楀埌鍥藉鑷劧绉戝鍩洪噾銆佸浗闄呰闂鑰呰鍒掋€佸洓宸濈渷鑷劧绉戝鍩洪噾绛夎仈鍚堣祫鍔┿€

鍘熸枃閾炬帴锛歨ttps://doi.org/10.1002/anie.202423117

 

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